CJC-1295_Ipamorelin Peptide

CJC-1295/ipamorelin Peptide has not yet been approved by the FDA for medical use; however, it has shown many potential benefits, including fat loss. Keep reading to learn more about these peptides. We also recommend talking to a healthcare professional before considering the peptides. If you want to talk to us about CJC-1295/ipamorelin peptide and weight loss, consult at My Concierge MD.

What are CJC-1295 and Ipamorelin?

CJC-1295 and Ipamorelin are proteins that stimulate the release of growth hormone. They work in tandem by increasing the concentration of growth hormone, which plays essential roles in cellular growth and metabolism along with offering other benefits.

While CJC-1295 belongs to Growth Hormone-Releasing Hormone (GHRH) analogs, Ipamorelin is a selective GHRH mimetic. In simple terms, GHRH is a hormone produced by the hypothalamus and acting on the anterior pituitary gland. It stimulates the release of growth hormone (GH) into the bloodstream, which promotes growth, cell reproduction, and regeneration.

What we know so far about CJC-1295 peptide is that it mimics the functions of growth hormones, but Ipamorelin doesn’t directly mimic GHRH. In fact, it activates ghrelin receptors to promote the release of growth hormones in a more controlled way than CJC-1295.

CJC-1295 and Ipamorelin mechanism

CJC-1295

  • GHRH Derivative: CJC-1295 is derived from growth hormone-releasing hormone (GHRH).
  • Target: It binds to the GHRH receptor (GHRH-R) in the anterior pituitary gland.
  • Effect: By acting as a GHRH-R agonist, CJC-1295 primarily increases GH levels.
  • Duration: It appears to elevate mean GH levels for extended periods, contributing to sustained effects

Ipamorelin

  • Selective Stimulation: Ipamorelin selectively stimulates the pituitary gland.
  • Receptor Binding: When administered, it binds to specific receptors in the pituitary gland.
  • Pulsatile Release: This triggers the release of GH in a pulsatile manner.
  • Short-Term Spikes: Ipamorelin induces short-term, supraphysiological spikes in GH synthesis

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Benefits of CJC-1295 and Ipamorelin

Let’s explore the benefits of CJC-1295 and Ipamorelin, two peptides that have garnered attention for their growth hormone-related effects:

CJC-1295

  • Enhanced Growth Hormone Levels: CJC-1295 acts as a GHRH analog, stimulating the release of growth hormone (GH) from the pituitary gland. This leads to increased GH levels in the bloodstream.
  • Longer Duration of Action: Unlike natural GHRH, CJC-1295 has a prolonged effect, maintaining elevated GH levels over an extended period.
  • Muscle Growth and Recovery: Higher GH levels contribute to muscle growth, repair, and recovery after exercise.
  • Anti-Aging Potential: Some studies suggest that CJC-1295 may have anti-aging properties due to its impact on GH secretion

Ipamorelin

  • Selective GH Stimulation: Ipamorelin specifically targets the pituitary gland, promoting the release of GH.
  • Pulsatile Release: It induces short bursts of GH secretion in a pulsatile manner.
  • Muscle Building: Ipamorelin supports muscle growth and strength.
  • Fat Loss: It aids in reducing body fat.
  • Bone Health: Ipamorelin may contribute to bone density and health.
  • Minimal Side Effects: Ipamorelin’s selectivity minimizes unwanted effects compared to other GH-releasing peptides.

Side Effects of CJC-1295 and Ipamorelin

  • Flushing
  • Nausea
  • Headaches
  • Fatigue
  • Abdominal pain
  • Dizziness

Side Effects of CJC-1295 and Ipamorelin

Are there any long-term effects or risks associated with using CJC-1295 and Ipamorelin?

Some women have found that CJC-1295/Ipamorelin supports their long-term health. However, this medication could cause changes in hormone levels that may interact with other medications (e.g., birth control or prescription drugs). It’s essential to consult with a doctor before beginning treatment.

Administration and dosage of CJC-1295 and Ipamorelin

CJC-1295 Dosage

Frequency: CJC-1295 can be dosed once to three times a day.

Weekly Dosage (for a 5-day week):

  • For 100-150 lbs: 1360-2040 μg (272-408 μg daily or 136-204 μg twice daily).
  • For 151-200 lbs: 2040-2720 μg (408-544 μg daily or 204-272 μg twice daily).
  • For 201-250 lbs: 2720-3400 μg (544-680 μg daily or 272-340 μg twice daily).

Ipamorelin Dosage

Frequency: Ipamorelin is typically dosed twice daily.

Daily Dosage (for a 5-day week):

  • For 100-150 lbs: 454-680 μg (227-340 μg twice daily or 151-227 μg thrice daily).
  • For 151-200 lbs: 681-908 μg (340-454 μg twice daily or 227-303 μg thrice daily).
  • For 201-250 lbs: 909-1134 μg (454-567 μg twice daily or 303-378 μg thrice daily).

CJC-1295/ipamorelin effectiveness

  1. A study found that subcutaneous CJC-1295 boosted growth hormone and IGF-I levels when given a certain dose. With multiple doses, this holds the potential as a treatment option. It could be used as a therapeutic agent to help manage health issues related to GH and IGF-I levels [1].
  2. Another study showed that growth-releasing hormones like Ipamorelin and GHRP-6 can increase bone mineral content (BMC) by promoting bone growth and dimensions without affecting bone mineral density in adult female rats [2].
  3. Another study suggested that when animals were given prednisolone (a type of steroid), their bodies broke down proteins faster. Growth hormones or Ipamorelin help slow this breakdown process, which means that GH or Ipamorelin can help treat the side effects of steroids [3].
  4. A 26-week growth therapy study showed a 13% decrease in subcutaneous fat, a 30% reduction in intra-abdominal fat, a 3-11% increase in lean body mass, an 11-19% improvement in aerobic function, and a 7-19% increase in muscle strength. These changes continued for a year, leading to a 22% overall fat reduction and 61% belly fat reduction within four months, persisting for up to three years [4].

CJC-1295/ipamorelin Near Me

My Concierge MD offers the best CJC-1295/ipamorelin near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

  1. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
  2. Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I, Ohlsson C, Jansson JO. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000 Jun;165(3):569-77. doi: 10.1677/joe.0.1650569. PMID: 10828840.
  3. Aagaard NK, Grøfte T, Greisen J, Malmlöf K, Johansen PB, Grønbaek H, Ørskov H, Tygstrup N, Vilstrup H. Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats. Growth Horm IGF Res. 2009 Oct;19(5):426-31. doi: 10.1016/j.ghir.2009.01.001. Epub 2009 Feb 23. PMID: 19231263.
  4. Mary Lee Vance, Mauras N. Growth Hormone Therapy in Adults and Children. The New England Journal of Medicine. 1999;341(16):1206-1216. doi:https://doi.org/10.1056/nejm199910143411607

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