Exosome Therapy

At My Concierge MD, we offer a range of exosome products that can be used to treat various conditions, including musculoskeletal injuries, degenerative diseases, skin aging and damage, chronic pain, and neurological disorders. The products are carefully sourced and rigorously tested to ensure their safety and efficacy for use in clinical practice.

Exosome therapy also delivers impressive hair growth with no reported side effects making this therapy option an attractive avenue to be explored. However, as this treatment is still new, there aren’t many clinical trials to confirm its efficacy and safety. The efficacy of the treatment for hair loss is still being reviewed, and the potential of exosome as an alternate therapy for hair restoration therapy is still being discussed.

What are Exosomes?

Exosomes are best described as extracellular vesicles that are released from target cells when the plasma membrane and the multivesicular body (MVB), an intermediate endocytic compartment, fuse.

Extracellular microvesicles/exosomes are small sacs that contain cells. The role of exosomes is to transfer and share information with other cells in your body (cell-to-cell communication). The information they share can change the function of the cells that are receiving the information. Messages your exosome sends to cells can tell them to heal your body in various ways.

Exosomes are involved in inflammatory processes that are crucial in a variety of pathologic conditions, including cancer, inflammatory bowel diseases, type 2 diabetes, obesity, rheumatoid arthritis, and neurodegenerative diseases.

Exosome Formation and Function

During a cell’s endocytosis phase, the cell’s membrane fuses to create endosomes. Inside the endosomes, the exosomes are formed. These exosomes can affect the cells they were released from or the ones they reach. As they travel throughout the body, they relay information and nutrients to the target cells. They perform various activities that influence immune responses, cell proliferation, and neuronal signaling.

In the field of medicine, they can help stimulate immune responses. They are also considered in the development of vaccines to treat certain cancers [1].

Exosome Sources

Exosomes are present in nearly all body fluids, including:

• Blood
• Urine
• Saliva
• Amniotic fluid
• Synovial fluid
• Semen
• Vaginal fluid
• Breast milk
• Serum and plasma from cancer patients

What is Exosome Therapy?

Exosome treatment is a form of regenerative medicine. It involves using exosomes to deliver therapeutic molecules to a specific type of cells in the body.

In exosome therapy, therapeutic molecules are delivered to particular cells in the body using exosomes, tiny vesicles that are naturally produced by regenerative cells. These exosomes include biomolecules that can be used to target particular cells and elicit the desired response, such as proteins, nucleic acids (DNA, RNA, mRNA, miRNAs, microRNA, etc.), and lipids. This is a novel medical procedure that is being researched for a range of potential uses.

The therapy is rapidly gaining recognition in the U.S. The administration of exosomes may provide benefits, according to some doctors. Studies suggest that there is a link between the health benefits of human mesenchymal regenerative cells (MSCs) and exosomes. Mesenchymal regenerative cell-derived exosomes have the highest count compared to any other cell.

Possible Benefits of Exosome Therapy

1. Skin rejuvenation

Our body’s ability to regenerate skin cells can dwindle as we age. This causes signs of aging, such as fine lines and wrinkles. Exosome therapy can helps promote the proliferation of fibroblast growth factors that are vital to skin strength and elasticity, producing anti-aging effects.

2. Promotes joint repair

Studies show that exosome therapy can help in the regeneration of articular cartilage. One of the benefits of exosomes is that they slow joint disease progress that naturally occurs with age.

Exosome therapy can speed up the healing process of the joint as it can help in the regeneration of articular cartilage. Exosomes can slow joint disease progress that naturally occurs with age. Exosome injections in the knees can bring relief from chronic pain to osteoarthritis patients. It can also help cure autoimmune diseases such as rheumatoid arthritis.

3. Enhanced Cognitive Function

A 2015 study conducted on rats suggested that after a traumatic brain injury using exosome therapy improved their motor function, learning ability, reduced inflammation and generated new cells in the brain [2].

Another 2017 study suggested exosomes derived from mesenchymal stromal cells promote axonal growth of cortical neurons [3].

4. Reduces inflammation

The body’s overactive immune responses can cause painful inflammation. Exosomes can help regulate it. The anti-inflammatory benefits of exosomes help in inflammation reduction, improving the symptoms and pain relief. It can also help in tissue regeneration.

The association between inflammation and change in nature or expression level of some exosomal cargos is the fundamental step for identifying possible novel biomarkers of inflammatory-based diseases [4].

5. Safer alternative to regenerative cell therapy

It is thought that regenerative cell therapies such as stem cells have the potential to cause health complications regarding cell replication. In some cases, regenerative cells and stem cells have the capability to morph into harmful cells. Exosomes can’t replicate and thus don’t have the same risk. Instead, exosomes stimulate the natural healing process and help it function more efficiently.

Risks of Exosome Therapy

1. Contamination

Exosomes in use that have not been properly extracted and sterilized may contain intercellular or extracellular genetic material from the MSCs that produced them. Potentially harmful genetic material exists. By sending the wrong signals to the cells, it may cause growth or abnormal cell development at the target site or in other parts of the body.

2. Limited understanding of exosome function

Although exosomes have been extensively studied, much remains unknown about their mechanisms of action and potential side effects. It is still unclear how different types of exosomes may affect different cell types and what the optimal dose and delivery route of exosomes may be for different diseases.

3. Potential for immunogenicity

Exosomes derived from foreign sources (antigen) or with modifications to their composition may trigger an immune response in the recipient, potentially leading to adverse effects or a lack of efficacy.

4. Long-term effects and safety

As with any new therapeutic approach, the long-term safety of exosome therapy is still unknown. It is possible that chronic exposure to exosomes or high doses may lead to unforeseen side effects or toxicities.

Differentiation between exosome therapy and other treatments

Exosome therapy is a brand-new and optimistic method of treating illnesses and conditions that differs in several ways from other therapies. The use of natural vesicles called exosomes, which are secreted by cells and contain a variety of biologically active molecules, in exosome therapy is one of the biggest differences. Unlike other treatments, which frequently rely on artificial substances or chemicals, this one is different.

Additionally, exosome therapy has a unique targeted delivery system that enables exosomes to deliver their contents specifically to selected cell types and tissues. This increases effectiveness while reducing the possibility of systemic toxicity. Exosome therapy is thus a versatile therapeutic choice with the potential to treat a range of illnesses. It can also kill cancer cells to help cure cancer, boost the immune system.

How long does exosome therapy last?

Regeneration and regrowth are not permanent. Hair loss will continue if you do not treat it to the desired level of growth. Exosomal hair loss treatments last an average of 6 to 9 months. It may take 6-8 months to improve skin collagen and boosts appearance.

Is there a way to prevent exosome therapy?

Exosome therapy is currently in the early stages of development, and it is not yet widely available or used in clinical practice. As such, there is no need to prevent exosome therapy at this time.

Exosome treatment near me

My Concierge MD offers the best Exosome Therapy near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

1. Rogers, Kara. “exosome”. Encyclopedia Britannica, 8 Sep. 2020, https://www.britannica.com/science/exosome. Accessed 25 January 2024.
2. Muthu S, Bapat A, Jain R, Jeyaraman N, Jeyaraman M. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig. 2021;8:7. Published 2021 Apr 2. doi:10.21037/sci-2020-037
3. Zhang Y, Chopp M, Meng Y, Katakowski M, Xin H, Mahmood A, Xiong Y. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg. 2015 Apr;122(4):856-67. doi: 10.3171/2014.11.JNS14770. Epub 2015 Jan 16. PMID: 25594326; PMCID: PMC4382456.