Dsip Peptide - MyConciergeMD

At My Concierge MD, we offer DSIP peptides as an option for patients seeking natural solutions to their sleep problems.  If you are interested in exploring the potential benefits of DSIP peptide, we encourage you to schedule a consultation with us. Don’t let sleep problems impact your quality of life any longer – contact us today to learn more about how DSIP peptide can benefit you.

A neuropeptide called a DSIP peptide also called a Delta Sleep Inducing Peptide, is created by the body on its own. Nine amino acids (known as nonapeptides) make up DSIP, which is a naturally occurring protein in the brain that may easily penetrate the BBB (blood-brain barrier). It is believed to be involved in the control of the human sleep pattern and is largely produced in the hypothalamus. Because DSIP levels are at their peak during deep sleep, it has earned a reputation as a inhibit somatostatin secretion and also a sleep-inducing substance. DSIP peptide can be found in both free and bound forms in the hypothalamus, limbic system, pituitary, and other locations, in addition to various peripheral organs, tissues, and cerebrospinal fluids.

The first time delta-sleep-inducing peptide (DSIP) was found was in the cerebral venous blood of rabbits that had undergone intraluminal thalamic electrical stimulation to induce sleep. Several species have reported the promotion of SWS following DSIP, albeit not all preclinical investigations were able to replicate these results. The effects of DSIP on sleep EEG in normal men have only been examined in one study, and it only found marginal effects. Controversial findings emerged from studies on the effectiveness of DSIP in the management of insomnia.

Is DSIP a hormone?

Although it is a naturally occurring peptide, DSIP (Delta Sleep-Inducing Peptide) is not a hormone. Endogenous body production occurs predominantly in the hypothalamus and pituitary gland.

DSIP does contribute to the modulation of some physiological processes even though it does not fit the description of a classical hormone, which is normally delivered into the bloodstream by specialized glands to regulate distant target tissues. DSIP may affect the production of hormones, including adrenocorticotropic hormone (ACTH) and cortisol, which are involved in the body’s stress response, as well as several neurotransmitter systems, including the GABAergic system.

Animals with ovariectomies were used to eliminate gonadal steroid feedback. GH was elevated in the initial experiment after the intraventricular injection of 5 micrograms of the peptide, which became substantial after 30 minutes and remained for the whole 120-minute session. Animals given diluent injections displayed a modest initial decrease in GH followed by no increase. With a minimum effective dose of 0.1 micrograms and a linear log-dose increase to a dose of 10 micrograms, the peptide increased plasma of the growth hormone in a dose-related manner. Since this effect could be prevented by pre-treating the rats with the dopamine receptor blocker pimozide, it is likely that this impact is mediated hypothalamically via a dopaminergic mechanism.

Does DSIP work for everyone?

While DSIP has shown encouraging effects in certain studies, it is crucial to note that individual responses can vary due to a variety of factors, such as underlying health issues, genetic variances, and general sleep patterns.

Does DSIP work for everyone - MyConciergeMD

Individual responses to any sleep aid or therapy intervention can also be influenced by a variety of factors, including the severity and underlying causes of chronic insomnia, pharmaceutical interactions, and individual biochem.

A radioimmunoassay was developed using antibodies produced in a rabbit by immunizing it with a synthetic version of the delta-sleep-inducing peptide (DSIP), which exhibited no cross-reactivity with any of the 19 naturally occurring peptides or their equivalents. N-Tyr-DSIP was created to prepare the tracer since DSIP cannot be easily iodinated using traditional techniques. Its dose-response curve was perfectly parallel to that of DSIP. Rat brain immunoreactivity analog to DSIP was discovered using this test. The thalamus had the highest concentrations in the brain (11.9 +/- 1.3 pg/mg).

What are the side effects of DSIP peptide?

The Swiss SchoenenbergerMonnier group initially discovered the sleep-inducing peptide delta (DSIP) from the cerebral venous blood of rabbits that had been put into induced sleep in 1974.

It should be noted that the information provided here is based on accessible research, and the negative effects of Delta Sleep Inducing Peptide (DSIP) may vary depending on the individual and dosage. The following are some of the probable negative effects that have been reported:

Impacts of hormones

It is thought that DSIP interacts with a variety of bodily enzymes and neurotransmitters. It might affect how much melatonin, cortisol, and growth hormone are released. These hormonal interactions’ precise effects and long-term ramifications, however, are still poorly known.

Sedation and drowsiness

DSIP peptide is recognized for its possible sedative and sleep-inducing properties. Though extreme sedation or drowsiness might interfere with everyday tasks and may not be acceptable for everyone, it can be desired for people looking to get better sleep.

Physiological consequences

Delta-sleep-inducing peptide has numerous physiological effects and involvement in endocrine control. It also has a function in the release of anterior pituitary hormones, the regulation of circadian rhythms, and the improvement of sleep efficiency.

In 1984, the isolation and characterization of delta-sleep-inducing peptide (DSIP) from 1963 to 1977 were reviewed. That work also contained the first studies describing the sleep and extra-sleep effects of DSIP. Only two years later, substantially more material on DSIP has accumulated. Aside from further research into the sleep-inducing and/or -supporting properties of DSIP in animals, significant effort has been done to investigate the peptide’s potential utility for medicinal purposes such as treatment of insomnia, pain, and withdrawal. Immunohistochemical and radioimmunochemical research added to our understanding of the nonpeptide’s natural occurrence and the distribution of DSIP-like material throughout the body, implying that the peptide may be linked to certain disorders.

Is DSIP Delta-Sleep-Inducing Peptide 5mg FDA-approved?

No, the United States Food and Drug Administration (FDA) has not approved DSIP (Delta-Sleep-Inducing Peptide) for any therapeutic application. DSIP is a research peptide and is not currently approved as a medicine or treatment for any medical condition. It has not been subjected to the thorough testing and regulatory scrutiny required for FDA approval.

Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Molecular Weight: 848.824 g/mol

Molecular Formula: C35H48N10O15

Dsip peptide near me

My Concierge, MD, Beverly Hills, offers the best DSIP (Delta-Sleep-Inducing Peptide) Peptides near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.


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  2. Iyer KS, McCann SM. Delta Sleep-Inducing Peptide (DSIP) stimulates Growth Hormone (GH) release in the rat by hypothalamic and pituitary actions. 1987;8(1):45-48. doi:https://doi.org/10.1016/0196-9781(87)90163-x
  3. Kastin AJ, Nissen C, Schally AV, Coy DH. Radioimmunoassay of DSIP-like material in rat brain. 1978;3(6):691-695. doi:https://doi.org/10.1016/0361-9230(78)90019-9
  4. Graf M, Kastin AJ. Delta-sleep-inducing peptide (DSIP): An update. 1986;7(6):1165-1187. doi:https://doi.org/10.1016/0196-9781(86)90148-8
  5. Buy. DSIP 5mg. PeptideSciences.com. Published 2019. Accessed May 21, 2023. https://www.peptidesciences.com/dsip-5mg

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