Ozempic Double Dose By Accident: What To Do Next?

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Ozempic Double Dose By Accident - My Concierge MD

If you’re managing your weight or type 2 diabetes with Ozempic, you know how essential it is to follow your prescribed dosage. 

However, accidents happen, and you feel a knot in your stomach because you accidentally took a double dose of Ozempic. You’re not alone. Cases of accidental overdoses of injectable weight-loss medications, including Ozempic, have skyrocketed by a staggering 1,500%, according to poison control centers.

Whether it’s a wave of nausea, persistent vomiting, or just a general feeling of unease, we’re here to help. This isn’t about judgment—mistakes happen. It’s about providing clear, compassionate guidance so you can take the next steps to feel better.

That’s why I have penned this post, compiling common questions like what constitutes an overdose, how to identify it, and what steps to take if you suspect you’ve doubled your dose.

Ozempic Double Dose By Accident: How Much Ozempic Constitutes An Overdose?

No set amount of Ozempic universally constitutes an overdose. While the maximum recommended dose for Ozempic is 2 mg per week, individual tolerance can vary, and some may experience overdose symptoms at lower doses.

Here are a few reports that state how Ozempic overdose has affected the patients.

  • Report 1: A 50-year-old man with type 2 diabetes injected himself with 0.5 ml of semaglutide instead of 0.05 ml. He suffered from 2 days of vomiting and 1 week of ongoing nausea but didn’t need hospital care.
  • Report 2: Another report states that a 37-year-old woman with obesity is taking 1 ml of semaglutide instead of 0.1 ml. The patient suffered from prolonged headaches, muscle weakness, and fatigue, but she, too, didn’t need emergency care.
  • Report 3: Another 33-year-old woman was emergency hospitalized due to nausea, vomiting, and abdominal pain after she received semaglutide in a spa (the dosage wasn’t specified).

Recommended Dosage

Understanding the recommended dosage is mandatory to know how much is too much. Here’s a quick walk-through:

  • Starting Dose: The initial dose is 0.25 mg once a week for the first 4 weeks. 
  • Maintenance Dose: After the initial 4 weeks, the dose is increased to 0.5 mg once a week. 
  • Dose Adjustment: If you need additional glycemic control, the dosage can be increased to 0.5 mg once per week.
  • Maximum Dose: After at least 4 weeks on the 1 mg dose, the dose can be increased to 2 mg once a week for further glycemic control.

Accidentally doubling your dose (e.g., taking 2 mg instead of your prescribed 1 mg) can cause serious health complications. More on health complications later.

How To Identify If You Have Taken Too Much Ozempic?

Recognizing the signs of an overdose can help you take swift action. Here are some signs to help you identify if you have taken too much of Ozempic:

  • Severe Nausea and Vomiting: If you feel intense nausea or vomiting beyond what you normally do after Ozempic, this is a potential sign of overdosing.
  • Rapid Heartbeat or Palpitations: If you get unusually fast or irregular heartbeats, palpitations, or fluttering sensations in your chest, it’s also a sign.
  • Dizziness or Fainting: Dizziness, lightheadedness, and even fainting can be signs of Ozempic overdose as well. This happens when it’s affecting your blood pressure or sugar levels.
  • Unusual Drowsiness or Lethargy: Do you feel abnormally tired, sleepy, or lethargic? This could be yet another sign of Ozempic overdose.
  • Abdominal Pain or Discomfort: Persistent or severe abdominal pain accompanied by nausea could indicate a change in the Ozempic dosage.

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What Are The Immediate Effects Of Taking Too Much Ozempic?

Immediate after-effects include the following:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Dizziness
  • Confusion
  • Drowsiness
  • Difficulty breathing
  • Irregular heartbeat
  • Chest pain
  • Seizures

We advise you to seek urgent medical attention if you’re experiencing any of these symptoms after taking Ozempic. 

Can Overdosing On Semaglutide Be Fatal?

The short answer is yes!

While overdosing on semaglutide is rare, it’s not unheard of. Prolonged vomiting and diarrhea can cause dehydration and electrolyte imbalances.

Moreover, a semaglutide overdose could also cause hypoglycemia (dangerously low blood sugar levels) if combined with other glucose-lowering medicines. Hypoglycemia could also be caused if a patient has underlying health conditions that affect blood sugar levels.

In extreme cases, an overdose of semaglutide could also cause cardiovascular or neurological effects due to blood pressure or sugar fluctuations. Too low blood sugar levels can cause death as well.

What Should You Do If You Overdosed On Ozempic?

Here is a list of what to do and what not to do when you are faced with such an issue:

Stay Calm

It may sound counterintuitive to stay calm when faced with a severe situation like this. While feeling anxious or concerned is understandable, staying calm can help you think clearly and take proper action.

Assess Your Symptoms

Note your symptoms. Check if you’re experiencing more than one of the symptoms listed above.

Contact Healthcare Provider

Once you identify the symptoms, call for help immediately. Provide detailed information on the medication, dosage, and timing to your healthcare provider.

Seek Emergency Medical Assistance

If your health condition worsens, call emergency services (911 in the U.S.) or go to the nearest emergency room.

Follow Medical Advice

Follow your doctor’s instructions. They may suggest medicine or consider other steps to tackle the problem. Be prepared to answer questions about your medical history, medication regime, and other vital information.

Do Not Attempt Self-Treatment

Self-treatment is a no-no! Avoid attempting to treat the overdose on your own. By doing so, you may make yourself vulnerable to serious health complications.

What Are The Long-Term Effects Of Ozempic Overdose?

The long-term effects of an Ozempic overdose are not well-documented if I am honest. This is because such cases are rare, and limited data is available. However, prolonged or repeated overdoses can cause these complications:

Gastrointestinal Issues

Chronic gastrointestinal symptoms such as nausea, vomiting, and diarrhea may persist if the gastrointestinal tract is continuously irritated by high levels of semaglutide.

Electrolyte Imbalance

As we’ve discussed above, prolonged vomiting and diarrhea from overdose can cause electrolyte imbalances. This may affect various bodily functions and can cause more complications.


Overdosing on semaglutide can cause dangerously low blood sugar levels (hypoglycemia). If hypoglycemia occurs frequently or persists over time, it could lead to complications such as seizures, loss of consciousness, or neurological damage.

Cardiovascular Effects

Semaglutide overdose may potentially affect cardiovascular function, leading to changes in heart rate, blood pressure, or cardiac rhythm. Prolonged exposure to high levels of the medication could increase the risk of cardiovascular events in patients.

Metabolic Effects

Chronic overdosing on Ozempic may disrupt metabolic processes in the body, potentially leading to imbalances in energy metabolism, lipid metabolism, or other metabolic pathways.

Renal or Hepatic Effects

Semaglutide overdose could potentially impact renal (kidney) or hepatic (liver) function, particularly if the medication is not adequately metabolized or cleared from the body.

How Does Ozempic Interact With Other Drugs If Overdosed?

Here are some considerations regarding drug interactions in the context of an Ozempic overdose:

  • Blood Glucose-Lowering Medications: When Ozempic is combined with other medications like insulin or sulfonylureas, it could increase the risk of hypoglycemia if overdosed.
  • Diuretics: Diuretics may cause dehydration resulting from vomiting and diarrhea due to Ozempic overdose.
  • Antiemetics: Antiemetic medications are used to treat nausea and vomiting. They may interact with Ozempic if taken during an overdose. Depending on the antiemetic type used, it can also aggravate overdose-related gastrointestinal symptoms.
  • Cardiovascular Medications: Medicines used to treat cardiovascular conditions (e.g., Beta-blockers or calcium channel blockers) may interact with Ozempic during an overdose. This could lead to heart rate, blood pressure, or cardiac rhythm changes. 
  • Electrolyte Replacement Therapy: This therapy becomes necessary when electrolyte imbalances occur due to dehydration. However, it needs to be done carefully to avoid worsening existing imbalances.
  • Other Diabetes Medications: Other diabetes medications, such as DPP-4 inhibitors or SGLT-2 inhibitors, may interact during Ozempic overdose. As a result, this can affect blood glucose levels and increase the risk of hypoglycemia.

What Is The Treatment For An Ozempic Overdose?

What Is The Treatment For An Ozempic Overdose - My Concierge MDThere are many ways the doctor can treat an ozempic overdose. Here are some notable ways:

  • Stabilization: This step involves monitoring vital signs, providing supportive care, and addressing any immediate concerns, such as dehydration or electrolyte imbalances.
  • Gastric Lavage: You may perform stomach pumping (gastric lavage) to remove any remaining Ozempic from the stomach. 
  • Activated Charcoal: Activated charcoal is useful for absorbing any remaining Ozempic in the GI tract to prevent absorption into the bloodstream.
  • Fluid Replacement: Intravenous (IV) fluids may be given to treat dehydration in case of an Ozempic overdose. Electrolytes may also be administered to correct any imbalances. 
  • Blood Glucose Monitoring: Continuous monitoring of blood glucose levels can help detect and manage hypoglycemia (low blood sugar) resulting from an Ozempic overdose. 
  • Symptomatic Treatment: Depending on your situation, your doctor may or may not prescribe antiemetics for nausea and vomiting.
  • Observation and Monitoring: Once the initial treatment is done carefully, your doctor will monitor you closely to track your progress, assess your response to treatment, or adjust therapy if needed.

How To Prevent An Ozempic Overdose?

There are a few steps you can take to prevent the Ozempic overdose. Let’s quickly have a look:

  • Follow Prescribed Dosage: Do not increase the dosage or dosing schedule without contacting your doctor first.
  • Use Proper Administration Technique: Follow the instructions provided in the medication package insert or as directed by your healthcare provider. If you don’t understand the instructions, seek help from your doctor.
  • Double-check the Dosing: Always double-check your prescribed dosage before taking them. Using medication reminders, medicine organizers, and keeping prescriptions nearby can help you avoid future overdoses. If you face concerns regarding your medications, communicate with your doctor.
  • Store Medication Safely: Keep Ozempic in its original packaging and store it according to the manufacturer’s instructions. Store it at the recommended temperature and away from heat, moisture, and direct sunlight.
  • Communicate with Your Doctor: I have already mentioned the importance of communicating with your doctor. Keep them informed about any changes in your medications, medical conditions, or other factors that may affect your treatment with Ozempic.
  • Educate Yourself: Take time off your busy schedule to learn more about Ozempic and its boons and banes. Some important points are dosage recommendations, administration guidelines, benefits, and side effects. Knowing the information can save your life!
  • Seek Medical Attention for Concerns: If you have any concerns about your medication regimen or experience symptoms that may indicate an overdose, seek help!
  • Keep Emergency Contacts Handy: Keep important contact information, including your healthcare provider’s phone number and the number for poison control, readily available in an emergency.

Final Words

Accidentally, taking a double dose of Ozempic can be a frightening experience, but knowing how to identify, respond to, and prevent such incidents can help you tackle the situation.

Always follow your prescribed dosage and consult your doctor with any concerns. Remember, your health and safety come first! And with the right approach, you can continue managing your condition confidently.

If you have any questions or need further guidance on using Ozempic safely, feel free to contact us. We’re here to support you on your health journey.

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